The Betaine attenuates the expression of vasoactive mediators and histological alterations associated with ovarian hyperstimulation syndrome in rats

Articles in Press

Document Type : Original Article

Authors

1 DVM Graduate, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

2 Shahid Chamran University of Ahvaz, Ahvaz, Iran

3 Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

10.22074/cellj.2024.2022353.1504

Abstract

Background: Ovarian hyperstimulation syndrome (OHSS) is one of the female reproductive disorders that can occur following the administration of injectable hormonal drugs to stimulate ovulation and due to the release of vascular dilator compounds from stimulated ovaries. The present study aimed to investigate the possible protective effects of betaine (BET) on vasoconstrictor proteins expression and ovarian histological changes and comparison of its effects with cabergoline (CAB) in an experimental model.

Materials and Methods: Thirty adult female 2-month-old rats were randomly divided into 6 experimental groups (n=5). The control group, OHSS group (10 UI, Sc of eCG and then 30 UI, Sc of hCG on the 5th day), OHSS+ BET (200 mg/kg/day, orally for 7 days), OHSS+ CAB (100 µg /kg/day, orally for 6 days), BET and CAB.

Results: Our finding demonstrated that OHSS induction resulted in an elevation of tissue changes, vascular dilator protein expression in the ovary, and increased estradiol and progesterone production. The administration of CAB and BET significantly these changes reduced.

Conclusions: The results of this study indicate the beneficial effects of BET in reducing the side effects of OHSS by reducing the expression of vasodilator proteins and also improving ovarian tissue changes in a process somewhat similar to the CAB chemical drug. Therefore, BET can be used to reduce the complications of ovarian hyperstimulation syndrome in patients and can be a new gate to open more research in the future.

Keywords

Cell Journal (Yakhteh)

Articles in Press, Accepted Manuscript
Available Online from 06 February 2024

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