Royan Institute First Attempts: Autotransplantation of Vitrified Human Ovarian Tissue in Cancer Patients

Document Type : Case Report

Authors

1 Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran

2 Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran

3 Department of Anatomy, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran

4 Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran

5 Department of Surgery, Iranmehr Hospital, Tehran, Iran

Abstract

Today, timely diagnosis and therapeutic progress open a road of hope for survival in cancerous patients. Increased
knowledge about the various cytotoxic treatment's impacts on ovarian function and fertility has resulted in a surge
in the number of patients seeking to preserve their fertility before starting the anti-cancer treatment process. In this
regard, embryo cryopreservation can be recommended for fertility preservation when the woman is married and has
adequate time for ovarian stimulation. If patients are prepubertal girls or not married women, oocytes or ovarian tissue
can be frozen instead to be used in the future. In this regard, the first attempts for ovarian tissue transplantations were
conducted in 2016 and in 2019 for two cancerous patients whose ovarian tissue was cryopreserved in the Royan
Human Ovarian Tissue Bank (Tehran, Iran). Unfortunately, the transplantations did not result in a live birth.

Keywords

Main Subjects

References

  1. Donnez J, Dolmans MM, Demylle D, Jadoul P, Pirard C, Squifflet J, et al. Livebirth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet. 2004; 364(9443): 1405-1410.
  2. Fraison E, Huberlant S, Labrune E, Cavalieri M, Montagut M, Brugnon F, et al. Live birth rate after female fertility preservation for cancer or haematopoietic stem cell transplantation: a systematic review and meta-analysis of the three main techniques; embryo, oocyte and ovarian tissue cryopreservation. Hum Reprod. 2023; 38(3): 489-502.
  3. Segers I, Bardhi E, Mateizel I, Van Moer E, Schots R, Verheyen G, et al. Live births following fertility preservation using in-vitro maturation of ovarian tissue oocytes. Hum Reprod. 2020; 35(9): 2026- 2036.
  4. Abtahi NS, Ebrahimi B, Fathi R, Khodaverdi S, Mehdizadeh Kashi A, Valojerdi MR. An introduction to the royan human ovarian tissue bank. Int J Fertil Steril. 2016; 10(2): 261-263.
  5. Ghezelayagh Z, Abtahi NS, Khodaverdi S, Rezazadeh Valojerdi M, Mehdizadeh A, Ebrahimi B. The effect of agar substrate on growth and development of cryopreserved-thawed human ovarian cortical follicles in organ culture. Eur J Obstet Gynecol Reprod Biol. 2020; 258(2): 139-145.
  6. Hornshøj Greve V, Dueholm M, Mamsen LS, Kristensen SG, Ernst E, Andersen CY. Hormonal characteristics of women receiving ovarian tissue transplantation with or without endogenous ovarian activity. J Clin Med. 2021; 10(22): 5217.
  7. Donnez J, Dolmans MM. Ovarian cortex transplantation: 60 reported live births brings the success and worldwide expansion of the technique towards routine clinical practice. J Assist Reprod Genet. 2015; 32(8): 1167-1170.
  8. Dolmans MM, von Wolff M, Poirot C, Diaz-Garcia C, Cacciottola L, Boissel N, et al. Transplantation of cryopreserved ovarian tissue in a series of 285 women: a review of five leading European centers. Fertil Steril. 2021; 115(5): 1102-1115.
  9. Gellert SE, Pors SE, Kristensen SG, Bay-Bjørn AM, Ernst E, Yding Andersen C. Transplantation of frozen-thawed ovarian tissue: an update on worldwide activity published in peer-reviewed papers and on the Danish cohort. J Assist Reprod Genet. 2018; 35(4): 561-570.
  10. Khattak H, Malhas R, Craciunas L, Afifi Y, Amorim CA, Fishel S, et al. Fresh and cryopreserved ovarian tissue transplantation for preserving reproductive and endocrine function: a systematic review and individual patient data meta-analysis. Hum Reprod Update. 2022; 28(3): 400-416.
  11. Amorim CA, Leonel ECR, Afifi Y, Coomarasamy A, Fishel S. Cryostorage and retransplantation of ovarian tissue as an infertility treatment. Best Pract Res Clin Endocrinol Metab. 2019; 33(1): 89-102.
Cell Journal (Yakhteh)
Volume 25, Issue 11 - Serial Number 118
November 2023
Pages 809-812

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