Royan Institute First Attempts: Autotransplantation of Vitrified Human Ovarian Tissue in Cancer Patients

Document Type : Case Report


1 Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran

2 Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran

3 Department of Anatomy, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran

4 Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran

5 Department of Surgery, Iranmehr Hospital, Tehran, Iran


Today, timely diagnosis and therapeutic progress open a road of hope for survival in cancerous patients. Increased
knowledge about the various cytotoxic treatment's impacts on ovarian function and fertility has resulted in a surge
in the number of patients seeking to preserve their fertility before starting the anti-cancer treatment process. In this
regard, embryo cryopreservation can be recommended for fertility preservation when the woman is married and has
adequate time for ovarian stimulation. If patients are prepubertal girls or not married women, oocytes or ovarian tissue
can be frozen instead to be used in the future. In this regard, the first attempts for ovarian tissue transplantations were
conducted in 2016 and in 2019 for two cancerous patients whose ovarian tissue was cryopreserved in the Royan
Human Ovarian Tissue Bank (Tehran, Iran). Unfortunately, the transplantations did not result in a live birth.


Main Subjects

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