Age-Related Skin Inflammation in A 2,4-Dintrochlorobenzene-Induced Atopic Dermatitis Mouse Model

Document Type : Short Communication

Authors

Department of Microbiology, College of Medicine, Ewha Womans University, Seoul, Republic of Korea

Abstract

One of the most affected aspects of the aging process is immunity, with age-related immune system decline being
responsible for an increase in susceptibility to infectious diseases and cancer risk. On the other hand, the aging
process is accompanied with low-grade pro-inflammatory status. This condition involves a persistent rise in cytokine
levels that can activate both innate and adaptive immune systems. Finally, despite the fact that immunological
responses to antigenic stimulations decrease with age, the incidence and prevalence of many common autoimmune
diseases increase in the elderly population. Overall, the co-existence of a prolonged, low-grade inflammatory status
and declining immune activity appears to be a paradoxical phenomenon. This study characterized skin inflammation in
mouse dermatitis model of various ages to monitor possible changes of inflammatory responses during aging.

Keywords

Main Subjects

References

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Cell Journal (Yakhteh)
Volume 25, Issue 9 - Serial Number 116
September 2023
Pages 660-664

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