Age-Related Skin Inflammation in A 2,4-Dintrochlorobenzene-Induced Atopic Dermatitis Mouse Model

Document Type : Short Communication


Department of Microbiology, College of Medicine, Ewha Womans University, Seoul, Republic of Korea


One of the most affected aspects of the aging process is immunity, with age-related immune system decline being
responsible for an increase in susceptibility to infectious diseases and cancer risk. On the other hand, the aging
process is accompanied with low-grade pro-inflammatory status. This condition involves a persistent rise in cytokine
levels that can activate both innate and adaptive immune systems. Finally, despite the fact that immunological
responses to antigenic stimulations decrease with age, the incidence and prevalence of many common autoimmune
diseases increase in the elderly population. Overall, the co-existence of a prolonged, low-grade inflammatory status
and declining immune activity appears to be a paradoxical phenomenon. This study characterized skin inflammation in
mouse dermatitis model of various ages to monitor possible changes of inflammatory responses during aging.


Main Subjects

  1. Neves J, Sousa-Victor P. Regulation of inflammation as an antiaging intervention. FEBS J. 2020; 287(1): 43-52.
  2. Medzhitov R. Inflammation 2010: new adventures of an old flame. Cell. 2010; 140(6): 771-776.
  3. Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, et al. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2017; 9(6): 7204-7218.
  4. Lee KA, Flores RR, Jang IH, Saathoff A, Robbins PD. Immune senescence, immunosenescence and aging. Front Aging. 2022; 3: 900028.
  5. Yousefzadeh MJ, Flores RR, Zhu Y, Schmiechen ZC, Brooks RW, Trussoni CE, et al. An aged immune system drives senescence and ageing of solid organs. Nature. 2021; 594(7861): 100-105.
  6. Ponnappan S, Ponnappan U. Aging and immune function: molecular mechanisms to interventions. Antioxid Redox Signal. 2011; 14(8): 1551-1585.
  7. Lian J, Yue Y, Yu W, Zhang Y. Immunosenescence: a key player in cancer development. J Hematol Oncol. 2020; 13(1): 151.
  8. Ray D, Yung R. Immune senescence, epigenetics and autoimmunity. Clin Immunol. 2018; 196: 59-63.
  9. Bektas A, Schurman SH, Sen R, Ferrucci L. Aging, inflammation and the environment. Exp Gerontol. 2018; 105: 10-18.
  10. Fulop T, Larbi A, Dupuis G, Le Page A, Frost EH, Cohen AA, et al. Immunosenescence and inflamm-aging as two sides of the same coin: friends or foes? Front Immunol. 2018; 8: 1960. 11. Legat FJ. Itch in atopic dermatitis - What is new? Front Med (Lausanne). 2021; 8: 644760
  11. Kapur S, Watson W, Carr S. Atopic dermatitis. Allergy Asthma Clin Immunol. 2018; 14(Suppl 2): 52.
  12. Nomura T, Wu J, Kabashima K, Guttman-Yassky E. Endophenotypic variations of atopic dermatitis by age, race, and ethnicity. J Allergy Clin Immunol Pract. 2020; 8(6): 1840-1852.
  13. Jang S, Ohn J, Kim JW, Kang SM, Jeon D, Heo CY, et al. Caffeoylpro- his amide relieve DNCB-induced atopic dermatitis-like phenotypes in BALB/c mice. Sci Rep. 2020; 10(1): 8417.
  14. Hong S, Lee B, Kim JH, Kim EY, Kim M, Kwon B, et al. Solanum nigrum Linne improves DNCBinduced atopic dermatitislike skin disease in BALB/c mice. Mol Med Rep. 2020; 22(4): 2878-2886.
  15. Min GY, Kim EY, Hong S, Kim JH, Kim M, Kim EJ, et al. Lycopus lucidus Turcz ameliorates DNCBinduced atopic dermatitis in BALB/c mice. Mol Med Rep. 2021; 24(6): 827.
  16. Choi J, Sutaria N, Roh YS, Bordeaux Z, Alphonse MP, Kwatra SG, et al. Translational relevance of mouse models of atopic dermatitis. J Clin Med. 2021; 10(4): 613.
  17. Zhang EY, Chen AY, Zhu BT. Mechanism of dinitrochlorobenzeneinduced dermatitis in mice: role of specific antibodies in pathogenesis. PLoS One. 2009; 4(11): e7703.
  18. Grabbe S, Schwarz T. Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity. Immunol Today. 1998; 19(1): 37-44.
  19. Watanabe H, Unger M, Tuvel B, Wang B, Sauder DN. Contact hypersensitivity: the mechanism of immune responses and T cell balance. J Interferon Cytokine Res. 2002; 22(4): 407-412.
  20. Tuckermann JP, Kleiman A, Moriggl R, Spanbroek R, Neumann A, Illing A, et al. Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy. J Clin Invest. 2007; 117(5): 1381-1390.