Potential Utilisation of Secretome from Ascorbic Acid-Supplemented Stem Cells in Combating Skin Aging: Systematic Review of A Novel Idea

Document Type : Systematic Review


1 Doctoral Program, Faculty of Medicine, Universitas Udayana, Denpasar, Indonesia

2 Histology Department, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia


The secretome of stem cells consists of a spectrum of bioactive factors secreted by stem cells grown in culture mediacytokines,
chemokines, and growth factors in addition to extracellular vesicles (exosomes and microvesicles). Ease
of handling and storage of secretomes along with their bioactivity towards processes in skin aging and customizability
makes them an appealing prospective therapy for skin aging. This systematic review aims to investigate the potential
usage of ascorbic acid (AA)-supplemented stem cell secretomes (SCS) in managing skin aging. We extracted articles
from three databases: PubMed, Scopus, and Cochrane. This review includes in vitro, in vivo, and clinical studies
published in English that discuss the correlation of AA-supplemented-SCS with skin aging. We identified 1111 articles
from database and non-database sources from which nine studies met the inclusion criteria. However, the study
results were less specific due to the limited amount of available research that specifically assessed the effects of AAsupplemented
SCS in skin aging. Although further studies are necessary, the AA modification of SCS is a promising
potential for improving skin health.


Main Subjects

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