Cellulose and Lignin-Derived Scaffold and Their Biological Application in Tissue Engineering, Drug Delivery, and Wound Healing: A Review

Document Type : Review Article


Stem cell research Center, Tabriz university of Medical Sciences, Tabriz, Iran


The goal of tissue engineering is to repair and regenerate diseased and damaged tissues and organs with functional
and biocompatible materials that mimic native and original tissues which leads to maintaining and improvement of
tissue function. Lignin and cellulose are the most abundant polymers in nature and have many applications in industry.
Moreover, recently the physicochemical behaviors of lignin and cellulose, including biocompatibility, biodegradability,
and mechanical properties, have been used in diverse biological applications ranging from drug delivery to tissue
engineering. To assess these aims, this review gives an overview and comprehensive knowledge and highlights the
origin and applications of lignin and cellulose-derived scaffolds in different tissue engineering and other biological
applications. Finally, the challenges for future development using lignin and cellulose are also included. Plant-based
tissue engineering is a promising technology for progressing areas in biomedicine, regenerative medicine, and
nanomedicine, with much research focused on the development of newer material scaffolds with individual specific
features to make functional and biocompatible tissues and organs for medical applications.



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