Ribosome Profiling: A Useful Approach To Discover Hidden Corners Of SARS-CoV-2

Zandi, Milad; Behboudi, Emad; Zeinali, Parisa; Soltani, Saber; Shojaei, Mohammad Reza

doi:10.22074/cellj.2022.8387

Ribosome Profiling: A Useful Approach To Discover Hidden Corners Of SARS-CoV-2

Document Type : Commentary

Authors

¹ Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

² Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran

³ Department of Biochemistry and Biophysics, School of Medicine, Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran

10.22074/cellj.2022.8387

Abstract

Following SARS-CoV-2 China epidemic in the December 2019, researches have attended to the genome of novel coronavirus. Hidden corners of SARS-CoV-2, maybe a shiny way to discover its pathogenicity and virulence. To design therapeutic agents, it is critical to map the complete repertoire of viral-translated proteins. Ribosome profiling is considered as a snapshot of all active ribosomes in a cell at a specific time point.

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