Ribosome Profiling: A Useful Approach To Discover Hidden Corners Of SARS-CoV-2

Document Type : Commentary


1 Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

2 Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran

3 Department of Biochemistry and Biophysics, School of Medicine, Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran


Following SARS-CoV-2 China epidemic in the December 2019, researches have attended to the genome of novel coronavirus. Hidden corners of SARS-CoV-2, maybe a shiny way to discover its pathogenicity and virulence. To design therapeutic agents, it is critical to map the complete repertoire of viral-translated proteins. Ribosome profiling is considered as a snapshot of all active ribosomes in a cell at a specific time point.