Stress Hormone and Oxidative Stress Biomarkers Link Obesity and Diabetes with Reduced Fertility Potential

Abbasihormozi, Shima; Babapour, Vahab; Kouhkan, Azam; Niasari Naslji, Amir; Afraz, Kaveh; Zolfaghary, Zahra; Shahverdi, Abdolhossein

doi:10.22074/cellj.2019.6339

Stress Hormone and Oxidative Stress Biomarkers Link Obesity and Diabetes with Reduced Fertility Potential

Document Type : Original Article

Authors

¹ Department of Basic Science, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

² Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran

³ Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran

⁴ 4Department of Regenerative Biomedicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

⁵ 5Department of Midwifery and Reproductive Diseases, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

⁶ 6Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran

10.22074/cellj.2019.6339

Abstract

Objective
Tilting the balance in favor of antioxidant agents could increase infertility problems in obese and diabetic individuals. The aim of this study was to evaluate oxidative stress status in semen of men with type 2 diabetes and obesity to investigate whether excessive amounts of oxidative stress, as a result of diabetes and obesity, influence infertility potential.
Materials and Methods
A case-control study was conducted in men (n=150) attending the Infertility Center of Royan Institute between December 2016 and February 2017. Participants were categorized into four groups; normal weight (BMI

Keywords