No Relationship between Serum and Salivary β2- Microglobulin Levels in A Sample of Adult Diabetic Men with Chronic Kidney Disease without Renal Replacement Therapy

Document Type : Original Article

Authors

1 Cardiovascular Research Center, Golestan Hospital , Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran

2 Department of Oral Medicine, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran

3 Diabetes Research Center, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran

4 4Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences (RIES), Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract

Objective
Β2-microglobulin (β2M) associated amyloidosis is an inevitable complication of chronic kidney disease (CKD). Testing β2M in the blood is invasive and expensive. On the other hand, oral fluid is a perfect medium to be explored for public health and disease surveillance. However, it has never been studied if salivary concentration of β2M reflects its concentration in the serum. The current study; therefore, aimed to examine the relationship between salivary and serum β2M in a sample of adult diabetic men with CKD.
Materials and Methods
Among diabetic patients referred to the Nephrology Department of The Golestan Hospital of Ahvaz due to CKD, 40 men not requiring renal replacement therapy were consecutively recruited for this cross-sectional study. Patients were excluded if they had any disease or were using any drugs that might affect the oral mucosa or saliva. The concentration of β2M was measured in both serum and saliva. The correlation between serum and salivary β2M was measured by calculating spearman’s ρ.
Results
The Spearman’s ρ for correlation between serum and salivary β2M was -0.017 (p=0.917), indicating lack of correlation. Serum and salivary creatinine (Spearman’s ρ=0.54; p value

Keywords

Cell Journal (Yakhteh)
Volume 16, Issue 2
May 2014
Pages 179-186

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