1. Malmström O, Morken NH. HELLP syndrome, risk factors in first and second pregnancy: a population-basedcohort study. Acta Obstet Gynecol Scand. 2018; 97(6): 709-716.
2. Webster K, Fishburn S, Maresh M, Findlay SC, Chappell LC; Guideline Committee. Diagnosis and management of hypertension in pregnancy: summary of updated NICE guidance. BMJ. 2019; 366: l5119.
3. Park HJ, Shim SS, Cha DH. Combined screening for early detection of pre-eclampsia. Int J Mol Sci. 2015; 16(8): 17952-17974.
4. Armaly Z, Jadaon JE ,Jabbour A, Abassi ZA. Preeclampsia: novel mechanisms and potential therapeutic approaches. Front Physiol. 2018; 9: 973.
5. Phipps E, Prasanna D, Brima W, Jim B. Preeclampsia: updates in pathogenesis, definitions, and guidelines. Clin J Am Soc Nephrol. 2016; 11(6): 1102.
6. Duhig K, Vandermolen B, Shennan A. Recent advances in the diagnosis and management of pre-eclampsia. F1000Res. 2018; 7: 242.
7. Mayrink J, Costa ML, Cecatti JG. Preeclampsia in 2018: Revisiting concepts, physiopathology, and prediction. ScientificWorldJournal. 2018; 2018: 6268276.
8. Kim SY, Kim HJ, Park SY, Han YJ, Choi JS, Ryu HM. Early Prediction of hypertensive disorders of pregnancy using cell-free fetal DNA, cell-free total DNA, and biochemical markers. Fetal Diagn Ther. 2016; 40(4): 255-262.
9. Hahn S, Rusterholz C, Hösli I, Lapaire O. Cell-free nucleic acids as potential markers for preeclampsia. Placenta. 2011; 32 Suppl: S17-S20.
10. Zhong XY, Gebhardt S, Hillermann R, Tofa KC, Holzgreve W, Hahn S. Parallel assessment of circulatory fetal DNA and corticotropinreleasing hormone mRNA in early-and late-onset preeclampsia. Clin Chem. 2005; 51(9): 1730-1733.
11. Han C, Han L, Huang P, Chen Y, Wang Y, Xue F. Syncytiotrophoblast- derived extracellular vesicles in pathophysiology of preeclampsia. Front Physiol. 2019; 10: 1236.
12. Palei AC, Granger JP, Tanus-Santos JE. Matrix metalloproteinases as drug targets in preeclampsia. Curr Drug Targets. 2013; 14(3): 325-334.
13. Rahat B, Sharma R, Bagga R, Hamid A, Kaur J. Imbalance between matrix metalloproteinases and their tissue inhibitors in preeclampsia and gestational trophoblastic diseases. Reproduction.
2016; 152(1): 11-22.
14. Palei AC, Sandrim VC, Amaral LM, Machado JS, Cavalli RC, Duarte G, et al. Association between matrix metalloproteinase (MMP)-2 polymorphisms and MMP-2 levels in hypertensive disorders of pregnancy. Exp Mol Pathol. 2012; 92(2): 217-221.
15. Espino Y, Sosa S, Flores-Pliego A, Espejel-Nuñez A, Medina-Bastidas D, Vadillo-Ortega F, et al. New insights into the role of matrix metalloproteinases in preeclampsia. Int J Mol Sci. 2017; 18(7): 1448.
16. Cabral-Pacheco GA, Garza-Veloz I, Castruita-De la Rosa C, Ramirez- Acuña JM, Perez-Romero BA, Guerrero-Rodriguez JF, et al. The roles of matrix metalloproteinases and their inhibitors in human diseases. Int J Mol Sci. 2020; 21(24): 9739.
17. Paiva P, Whitehead C, Saglam B, Palmer K, Tong S. Measurement of mRNA transcripts of very high placental expression in maternal blood as biomarkers of preeclampsia. J Clin Endocrinol Metab. 2011; 96(11): E1807-E1815.
18. Wu P, van den Berg C, Alfirevic Z, O’Brien S, Röthlisberger M, Baker PN, et al. Early pregnancy biomarkers in pre-eclampsia: a systematic review and meta-analysis. Int J Mol Sci. 2015; 16(9): 23035-23056.
19. Whitehead CL, Walker SP, Tong S. Measuring circulating placental RNAs to non-invasively assess the placental transcriptome and to predict pregnancy complications. Prenat Diagn. 2016; 36(11): 997-1008.
20. Arpino V, Brock M, Gill SE. The role of TIMPs in regulation of extracellular matrix proteolysis. Matrix Biol. 2015; 44-46: 247-254.
21. Mendes S, Timóteo-Ferreira F, Almeida H, Silva E. New insights into the process of placentation and the role of oxidative uterine microenvironment. Oxid Med Cell Longev. 2019; 2019: 9174521.
22. Tarca AL, Romero R, Erez O, Gudicha DW, Than NG, Benshalom- Tirosh N, et al. Maternal whole blood mRNA signatures identify women at risk of early preeclampsia: a longitudinal study. J Matern Fetal Neonatal Med. 2021; 34(21): 3463-3474.
23. Ashur-Fabian O, Yerushalmi GM, Mazaki-Tovi S, Steinberg DM, Goldshtein I, Yackobovitch-Gavan M, et al. Cell free expression of hif1α and p21 in maternal peripheral blood as a marker for preeclampsia and fetal growth restriction. PLoS One. 2012; 7(5): e37273.
24. Zhu J, Zhong M, Pang Z, Yu Y. Dysregulated expression of matrix metalloproteinases and their inhibitors may participate in the pathogenesis of pre-eclampsia and fetal growth restriction. Early
Hum Dev. 2014; 90(10): 657-664
25. Xiang Y, Zhang X, Li Q, Xu J, Zhou X, Wang T, et al. Promoter hypomethylation of TIMP3 is associated with pre-eclampsia in a Chinese population. Mol Hum Reprod. 2013; 19(3): 153-159.
26. Sandrim V, Machado J, Tanus-Santos JE, Cavalli R. 41 Circulating level of TIMP-4 is elevated in preeclampsia: endothelial dysfunction, anti-angiogenic factors. Pregnancy Hypertension: An International Journal of Women’s Cardiovascular Health. 2016; 6(3): 197.
27. Nikolov A, Popovski N, Hristova I. Collagenases MMP-1, MMP-13, and tissue inhibitors TIMP-1, TIMP-2: their role in healthy and complicated pregnancy and potential as preeclampsia biomarkers—a brief review. Appl Sci. 2020; 10(21): 1-13.
28. Tomimatsu T, Mimura K, Matsuzaki S, Endo M, Kumasawa K, Kimura T. Preeclampsia: maternal systemic vascular disorder caused by generalized endothelial dysfunction due to placental antiangiogenic factors. Int J Mol Sci. 2019; 20(17): 4246.
29. Zhang Y, Li P, Guo Y, Liu X, Zhang Y. MMP-9 and TIMP-1 in placenta of hypertensive disorder complicating pregnancy. Exp Ther Med. 2019; 18(1): 637-641.
30. Nissi R, Santala M, Talvensaari-Mattila A. The serum levels of circulating matrix metalloproteinase MMP-9, MMP-2/TIMP-2 complex and TIMP-1 do not change significantly during normal pregnancy: a pilot study. BMC Res Notes. 2021; 14(1): 31.
31. Seval Y, Akkoyunlu G, Demir R, Asar M. Distribution patterns of matrix metalloproteinase (MMP)-2 and-9 and their inhibitors (TIMP-1 and TIMP-2) in the human decidua during early pregnancy. Acta Histochem. 2004; 106(5): 353-362.
32. Nikolov A, Popovski N. Role of gelatinases MMP-2 and MMP-9 in healthy and complicated pregnancy and their future potential as preeclampsia biomarkers. Diagnostics (Basel). 2021; 11(3): 480.
33. Xie D, Zhu J, Liu Q, Li J, Song M, Wang K, et al. Dysregulation of HDAC9 represses trophoblast cell migration and invasion through TIMP3 activation in preeclampsia. Am J Hypertens. 2019; 32(5): 515-523.
34. Kuliczkowski W, Radomski M, Gąsior M, Urbaniak J, Kaczmarski J, Mysiak A, et al. MMP-2, MMP-9, and TIMP-4 and response to aspirin in diabetic and nondiabetic patients with stable coronary artery disease: a pilot study. BioMed Res Int. 2017; 2017: 9352015.
35. Masciantonio MG, Lee CKS, Arpino V, Mehta S, Gill SE. The balance between metalloproteinases and TIMPs: critical regulator of microvascular endothelial cell function in health and disease. Prog Mol Biol Transl Sci. 2017; 147: 101-131.
36. Majali-Martinez A, Hiden U, Ghaffari-Tabrizi-Wizsy N, Lang U, Desoye G, Dieber-Rotheneder M. Placental membrane-type metalloproteinases (MT-MMPs): key players in pregnancy. Cell Adh Migr. 2016; 10(1-2): 136-146.
37. Chen J, Khalil RA. Matrix metalloproteinases in normal pregnancy and preeclampsia. Prog Mol Biol Transl Sci. 2017; 148: 87-165.