Modified Bismuth Nanoparticles: A New Targeted Nanoprobe for Computed Tomography Imaging of Cancer

Document Type : Original Article


1 Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

2 Department of Radiology Technology, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran

3 Department of Medical Physics, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

4 Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

5 Medical Physics and Radiology Department, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran


Objective: Recently, development of multifunctional contrast agent for effective targeted molecular computed
tomography (CT) imaging of cancer cells stays a major problem. In this study, we explain the ability of Triptorelin
peptide-targeted multifunctional bismuth nanoparticles (Bi2S3@ BSA-Triptorelin NPs) for molecular CT imaging.
Materials and Methods: In this experimental study, the formed nanocomplex of Bi2S3@ BSA-Triptorelin NPs
was characterized using different methods. The MTT cytotoxicity test was performed to determine the appropriate
concentration of nanoparticles in the MCF-7 cells. The X-ray attenuation intensity and Contrast to Noise Ratio (CNR) of
targeted and non-targeted nanoparticles were measured at the concentrations of 25, 50, and 75 μg/ml and X-ray tube
voltages of 90, 120 and 140 kVp.
Results: We showed that the formed Bi2S3@ BSA-Triptorelin NPs with a Bi core size of approximately ~8.6 nm are nontoxic
in a given concentration (0-200 μg/ml). At 90, 120, and 140 tube potentials (kVp), the X-ray attenuation of targeted cells were
1.35, 1.36, and 1.33-times, respectively, more than non-targeted MCF-7cells at the concentration of 75 μg/ml. The CNR
values at 90, 120, and 140 kVp tube potentials were 171.5, 153.8 and 146.3 c/ϭ, respectively.
Conclusion: These findings propose that the diagnostic nanocomplex of Bi2S3@ BSA-Triptorelin NPs can be applied
as a good contrast medium for molecular CT techniques.


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