Document Type : Review Article
Authors
1
Exercise Physiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran;Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Teh
2
Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
3
Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran;Department of Anatomy, Faculty of Medical Sciences, Tarbiat Modares University, Tehra
4
4Physiology Graduate Program, North Carolina State University, Raleigh, NC, USA
5
Exercise Physiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran;5Aerospace and Subaquatic Medicine Faculty, Aerospace Medicine Research Center, AJA Medical Sciences University, Tehran, Ira
Abstract
Satellite cells (SCs) are the most abundant skeletal muscle stem cells. They are widely recognized for their contributions to maintenance of muscle mass, regeneration and hypertrophy during the human life span. These cells are good candidates for cell therapy due to their self-renewal capabilities and presence in an undifferentiated form. Presently, a significant gap exists between our knowledge of SCs behavior and their application as a means for human skeletal muscle tissue repair and regeneration. Both physiological and pathological stimuli potentially affect SCs activation, proliferation, and terminal differentiation the former category being the focus of this article. Activation of SCs occurs following exercise, post-training micro-injuries, and electrical stimulation. Exercise, as a potent and natural stimulus, is at the center of numerous studies on SC activation and relevant fields. According to research, different exercise modalities end with various effects. This review article attempts to picture the state of the art of the SCs life span and their engagement in muscle regeneration and hypertrophy in exercise.
Keywords
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