Methods for Isolation of Bone Marrow Stem Cells: Comparative Analysis

Document Type : Review Article

Authors

1 Department of Regenerative Biomedicine and Cell Terapy, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

2 Department of Stem Cells and Developmental Biology, Cell Sciences Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

3 Department of Developmental Biology, University of Science and Culture, ACECR, Tehran, Iran

Abstract

During the past decade, regenerative medicine has emerged as a key technology in the
next generation of medical care, and cell therapy and organ repair using stem cells have
become very attractive options for regenerative medicine. The application of stem cells in
regenerative medicine has required modified methods for isolation. Furthermore, the process
of cell separation plays an important role in cell therapy and regenerative medicine
using stem cells. So, in this review, we compare different methods for the separation of
cells from bone marrow for transplantation to humans, with emphasis on the advantages
and disadvantages of each method.

Keywords