Objective: To describe the effect of varicocele, in an experimental rat model, on the levels of IL-1β and IL-1 β proteins in testis tissue. Design: Comparative and controlled study. Setting: Experimental research. Animal(s): Wistar male rats in experimental and control groups. Intervention(s): The control group underwent sham operation (n_6). Experimental groups underwent partial ligation of the renal vein to induce experimental varicocele and were then killed at 9(n_6), 11(n_6), and 13(n_6) weeks after induction of varicocele. Main Outcome Measures: Histologic evaluation of the varicocele model was determined by periodic acid-Schiff staining of paraffin-embeded testicular tissues. Levels of cytokines were assessed by mmunohistochemistry and Western blot analysis. Results: Varicocele caused testicular damage, especially in 11- and 13-week-old varicocele groups. In sham-operated rats, Golgi complexes of round spermatids expressed especially the_form of IL-1. By the progression of varicocele, the IL-1_xpression increased temporally in Sertoli cells, spermatogonia, primary spermatocytes, spermatids, and Leydig cells. The expression of IL-1_was seen in Leydig cells in shamoperated rats. The IL-1_ expression was also increased upon progression of varicocele in Leydig cells, Sertoli cells, and spermatogonia. Conclusion: We suggest that IL-1_ and IL-1_ are the regulators of testicular function. Certain pathologic conditions, e.g., varicocele, cause an increase in the expressions of such proinflammatory cytokines. The increased expression of IL-1_ and IL-1_ in varicocele shifts the balance in favor of inflammatory and immune responses and causes detrimental effects in testis tissue, which may cause male infertility.
Z, S., C, C., G, A., E, T. K., N, A., T, E., R, D., & I, U. (2007). Increased Expression OfInterleukin-1Beta And Interleukin-1? Is Associated With ExperimentalVaricocele. Cell Journal (Yakhteh), 9(supplement1), -.
MLA
Sahin Z; Celik-Ozenci C; Akkoyunlu G; Turkay Korgun E; Acar N; Erdogru T; Demir R; Ustunel I. "Increased Expression OfInterleukin-1Beta And Interleukin-1? Is Associated With ExperimentalVaricocele". Cell Journal (Yakhteh), 9, supplement1, 2007, -.
HARVARD
Z, S., C, C., G, A., E, T. K., N, A., T, E., R, D., I, U. (2007). 'Increased Expression OfInterleukin-1Beta And Interleukin-1? Is Associated With ExperimentalVaricocele', Cell Journal (Yakhteh), 9(supplement1), pp. -.
VANCOUVER
Z, S., C, C., G, A., E, T. K., N, A., T, E., R, D., I, U. Increased Expression OfInterleukin-1Beta And Interleukin-1? Is Associated With ExperimentalVaricocele. Cell Journal (Yakhteh), 2007; 9(supplement1): -.
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