Effects Of Fundermol Ointment On Epithelialization Of Third Degree Burn Wound



Introduction: Concerning that third degree burn wounds have no real practical treatment other than invasive methods, this study reports on the therapeutic effects of a newly formulated ointment "fundermol" on accelerating the burn wound healing.
Materials & Methods: Forty five male and female Albine-N-Mari rats weighing 160 to 180 g were anaesthesized with intraperitoneal injection of pentobarbital and burned by Steam in a way making third degree burn wound on their back 33 mm length in diameter. Then animals were randomly asigned to fundermol, silver sulfadiazine, and control groups. On post-wounding days 7, 14, and 28, the animals were sacrificed with ether and similar samples were excised in all groups. Epithelialization of wounds was evaluated in terms of histological analysis and morphometric assessment.
Results: The statistical results indicate that Fundermol ointment increases the epithelialization of third degree burn wounds and leads to wound closure. We assume that the increase in vascularity of the wound bed and the support of the hair follicles as the result of the fundermol usage (24,25) can lead to a better epithelialization procedure. Also anti inflamatory and anti bacterial effects of the ointment may ease this procedure. Of course the exact mechanisms involving the therapeutic effects of this herbal ointment is yet to be studied.
Conclusion: As fundermol ointment is a natural product and there is no report on the side effects of the drug components, these findings may suggest a therapeutic clue in clinical management of third degree burn wounds.