The Effect Of Varicocelectomy On Sperm Parameters, Membrane Integrity And Sperm Chromatin Condensation

Document Type : Original Article



Introduction: Varicocele is considered as a common cause of male infertility. The aim of this study was to evaluate the effects of varicocelectomy on sperm parameters, sperm membrane integrity and sperm nuclear maturity.
Materials and Methods: In this study along with routine semen analysis, hypo-osmotic swelling test (HOST), and aniline blue staining for assessment of as 45 and 90 days after it.membrane integrity and nuclear maturity was carried out on 20 patient before operation as well
Result: The analysis of the data showed an improvement in total sperm concentration and morphology after operation (P<0.05). Sperm nuclear maturity also showed a significant improvement after varicocelectomy, however no change was observed in mean HOST score before and after varicocelectomy.
Conclusion: Varicocele impairs semen parameters and to certain extent sperm nuclear maturity, however it does not have any effect on membrane integrity. The improvement in semen parameters specially sperm density, morphology, and nuclear maturity might improve pregnancy rate after varicocelectomy.