The Study Of Embryotoxic Effects Of Phenol In Mice Embryo

Document Type : Original Article


Anatomy Department, Mashhad Medical Sciences University, Mashhad, Iran


Introduction: It is clear that the phenol can absorb through skin and mucosal surfaces, and affect on different systems of body and ultimatly cause death. Furthermore during the pregnancy, phenol may pass through the placental barrier and therefore enter the embryonic circulation and effect on organogenesis. The aim of this investigation was to study the embryonic effects of phenol in the devloping mice embryo.
Materials and Methods: In this study pregnant mice (experimental group) received 100 mg/kg phenol via interaperitoneally injection during 8, 9 and 10 postmating days. The same manner control group was received physiological serum. At the last day of pregnancy, all of cases (experimental and control) were anesthetized, sacrificed and their fetuses collected and examined. In addition their weight and Crown Rump (CR) measured.
Results: The result show a decrease in number of fetuses, high incidence of growth retardation in (P<0.05) and decrease of CR (P<0.005) in experimental group. Furthermore, absorption and mortality among fetuses experimental group as compared with control group (P<0.001).
Conclusion: This study suggested that the phenol crosses placenta and able to produce embryotoxicity and embryolethality in experimental group.