The Effects Of Bromocriptine Injection In Ventromedial Nucleus Of Hypothalamus On Food And Water Intake As Well As Gain In Adult Male Rats

Document Type : Original Article


Phisiology Department, Tehran Medical University, Tehran, Iran


Introduction: Dopamine is one member of catecholamine, which has a crusial role in the regulation of feeding behavior. The Peripheral injection of dopamine agonistssuch as bromocriptine causes anorexia. The aim of this study is to show how this drugacts. The reason for this selection is due to its importance in the regulation of food intake.
Materials & Methods: Sixty three adult male rats (280-320 gw) were used. The rats were divided in to nine groups as follows: control, sham B (injected vehicle of bromocriptine), Br12.5, Br25, Br50 (injected bromocriptin respectively 12.5,25 and g), SBr (injected sulpiride + bromocriptine), ScBr (injected ScH2339 + bromocriptine), ShSBr and ShScBr of which the last two cases are sham respectively. The injection intervals were 24h, which took 7 days. All of them were bilaterally. Food, water intake and weight measured 24 hours after each injection and the following results were obtained.
Results: Bromocriptine showed a decrease in food, water intake and weight gain. Sulpiride antagonized the effects of bromocriptine on food, water intake and weight gain. ScH23390 caused no significant changes in bromocriptine effects on food, water intake and weight gain.
Conclusion: These results indicate that, the D2 dopamine receptors of VMN have acrusial role in decreasing effects of bromocriptine on feeding behaviors.