Study Of Renal Glomerular Mesangium And Volume Changes In Alloxan Induced Diabetic Rat

Document Type : Original Article


Anatomy Department, Mashhad Medical Sciences University


Introduction: Kidney is one of the target organs in diabetes mellitus. Diabetic nephropathy is a major cause of end stage-renal disease and resulting an increased in morbidity and mortality of effected individuals. Since diabetes is a progressive disease, therefore early diagnosis leads to better treatment. In this study primary diagnostic parameters were the goal.
Materials and Methods: In this study morphometrical and stereological methods and stains of H&E and PAS were applied. Experimental rats were classified in to two groups, 8 and 17 weeks after treatment, the animals with alloxan.
Results: 17 weeks diabetic rats showed increased in glomerular measangium and glomerular volume.
Conclusion: Therefor this study showed that glomerular changes happen in earlier time can be an early diagnosis method in affected kidney.