Physiology Department, School of Medicine, Tarbiat Modarres University, Tehran, Iran
Abstract
Introduction: The role of adenosine A1 receptors of the amygdala on entorhinal cortex kindled seizures was investigated. Material and Methods: Animals were kindled by daily electrical stimutation of entorhinal cortex. In the full kindled animals, N6-cyclohexyladenosine (CHA 10, 50, 100, 500óM), an adenosine A1 receptor agonist and 8-cyclopentyl- 1, 3, dimethylxanthine (CPT, 10, 20 óM), an adenosine A1 receptor antagonist, were microinfused into the amygdala. Results: Data showed that CHA, only at a concentration of 500óM, decreaed entorhinal cortex and amygdala after discharge duration, stage 5 duration and seizure duration seizure duration and increased patency to stage 4 at 15 min post drug injection. Intraamygdala injection of CPT showed that it only at a concentration of 20 óM, reduced patency to stage 4. Intraamygdala pretreatment of animals by intraamygdala injection of CPT (10 óM), 5 min before CHA (500 óM), resulted in blockage of anticonvulsant effects of CHA. Conclusion: These results suggest that the amygdala may have a moderate role in seizure propagation from the entorhinal cortex and its adenosine A1 receptor activity has anticovulsant effects on entorhinal cortex kindled seizures.
Amini Komijani, A., Mirnajafi-Zadeh, S., Fathollahi, Y., & Motamedi, F. (2003). Effect Of Adenosine A1 Recertors Of Amygdala On Entorhinal Cortex Kindled Seizures In Rat. Cell Journal (Yakhteh), 5(3), 137-143.
MLA
A. Amini Komijani; SJ. Mirnajafi-Zadeh; Y. Fathollahi; F. Motamedi. "Effect Of Adenosine A1 Recertors Of Amygdala On Entorhinal Cortex Kindled Seizures In Rat". Cell Journal (Yakhteh), 5, 3, 2003, 137-143.
HARVARD
Amini Komijani, A., Mirnajafi-Zadeh, S., Fathollahi, Y., Motamedi, F. (2003). 'Effect Of Adenosine A1 Recertors Of Amygdala On Entorhinal Cortex Kindled Seizures In Rat', Cell Journal (Yakhteh), 5(3), pp. 137-143.
VANCOUVER
Amini Komijani, A., Mirnajafi-Zadeh, S., Fathollahi, Y., Motamedi, F. Effect Of Adenosine A1 Recertors Of Amygdala On Entorhinal Cortex Kindled Seizures In Rat. Cell Journal (Yakhteh), 2003; 5(3): 137-143.