Free Radicals And Antioxidants “Oxidative Stress” In Cadmium Exposure Workers


1 Biology Department, Arak University

2 Biology Department, Shazand Payame Noor University


Oxidative stress arises when there is a marked imbalance between the production and removal of reactive oxygen species that may lead to several diseases. Cadmium is an environmental and industrial pollutant that results in formation of free radicals. The aim of this study was to determine the oxidative stress status in cadmium exposure workers. This is a cross-sectional study of 36 people of cadmium exposure workers with two years employment records who were randomly selected as the case group and 36 other people who were selected with matched age and gender as the control group. Both groups were compared for the different parameters of oxidative stress. The mean and standard deviation (mean SD) of the total antioxidant capacity of serum was 2.9+0.9 in case group and 2.4+1.2 in control group (p=0.003). The rate of lipid peroxidation was 7.2+3.4 in case group and 9.3+3.6 in control group (p=0.015). The rate of total thiol group was 34+243 in case group and 0.246+0.114 in control group (p=0.004). The results of the study indicated that following exposure to cadmium, their TAC and thiol group antioxidants markedly enhanced to retaliate the influence of excessive reactive oxygen radicals. This decreased lipid peroxidation.