Matrix Metalloproteinase’s Role In Producing And Curing Of Liver Fibrosis


1 Stem Cells and Developmental Biology Department, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

2 Developmental Biology Department, University of Science and Culture, ACECR, Tehran, Iran


Matrix metalloproteinases are a zinc and calcium dependent endopeptidase family that are expressed in injured tissue such as cardiovascular or hepatic disease. Complex efforts of this enzymes on the extra cellular matrix structure is related to up and down regulation of them and their tissue inhibitors. Configuration of extra cellular matrix during pathogenesis, curing and development is affected by two key mechanisms: matrix metalloproteinase and hepatic stellate cell activity. The important role of these enzymes on liver injuries and regeneration are indicated when their effects on migration of bone marrow stem cells and hepatic stem cells was discoverd.