MEDICAL BIOLOGY RESEARCH CENTER, KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES, SORKHEH LIZHEH, KERMANSHAH, IRAN
Angiogenesis the development of new blood vessels from existing vasculature is essential in physiological processes such as growth and development wound healing and reproduction. It is also involved in pathological conditions such as tumor growth metastases and certain chronic diseases. Angiogenesis is dependent on a delicate equilibrium between endogenous angiogenic and antiangiogenic factors. However under pathological conditions this tight regulation becomes lost which can result in the formation of the different diseases including corneal neovascularization endometriosis obesity atherosclerosis diabetic retinopathy psoriasis and cancer. In general the process of angiogenesis is a multi-factorial and highly structured sequence of cellular events comprising migration proliferation and differentiation of endothelial cells and finally vascular formation maturation and remodelling. Due to the critical role of angiogenesis in physiological and pathological conditions scientists have designed various experimental models to assay angiogenesis in vitro ex vivo and in vivo. Currently many researchers profit from these experimental models that have been created for numerous research applications such as many angiogenic and antiangiogenic factors which can be used to discover of therapeutic applications.