TY - JOUR ID - 703269 TI - The Effect of Amniotic Membrane Extracted Eye Drop on Repairing The Corneal Epithelial in Patients after Trans-Epithelial Photorefractive Keratectomy: An Interventional and Historical Study JO - Cell Journal (Yakhteh) JA - CELLJ LA - en SN - 2228-5806 AU - Ranaei, Alireza AU - Chavoshi, Ahmad AU - Aghamollaei, Hossein AU - Naderi, Mostafa AU - Agha Alishiri, Ali AU - Jadidi, Khosrow AD - Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran AD - Chemical Injures Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran Y1 - 2023 PY - 2023 VL - 25 IS - 4 SP - 217 EP - 221 KW - Amnion KW - Photorefractive Keratectomy KW - Refractive Surgical Procedures KW - Wound healing DO - 10.22074/cellj.2022.8165 N2 - Objective: Recent studies imply extensive applications for the human amniotic membrane (hAM) and its extract inmedicine and ophthalmology. The content of hAM meets many requirements in eye surgeries, such as refractivesurgery as the most important and commonly used method for treating the dramatically increasing refractive errors.However, they are associated with complications such as corneal haziness and corneal ulcer. This study was designedto evaluate the impact of amniotic membrane extracted eye drop (AMEED) on Trans-PRK surgery complications.Materials and Methods: This interventional and historical study was performed during two years (July 1, 2019-September1, 2020). Thirty-two patients (64 eyes), including 17 females and 15 males, aged 20 to 50 years (mean age of 29.59 ±6.51) with spherical equivalent between -5 to -1.5 underwent Trans Epithelial Photorefractive Keratectomy (Trans-PRK)surgery. One eye was selected per case (case group) and the other eye was considered as control. Randomizationwas done using the random allocation rule. The case group was treated with AMEED, and the artificial tear drop every4 hours. The control eyes received artificial tear drops instilled every 4 hours. The evaluation continued for three daysafter the Trans-PRK surgery.Results: A significant decrease in CED size was found in the AMEED group on the second day after surgery (P=0.046).Also, this group had a substantial reduction in pain, hyperemia, and haziness.Conclusion: This study showed that AMEED drop can increase the healing rate of corneal epithelial lesions after Trans-PRK surgery and reduce the early and late complications of Trans-PRK surgery. Researchers and Ophthalmologistsshould consider AMEED as a selection in patients with persistent corneal epithelial defects and patients who havedifficulty in corneal epithelial healing. We understood AMEED has a different effect on the cornea after surgery;therefore, the researcher must know AMEED’s exact ingredients and help expand AMEED uses. UR - https://www.celljournal.org/article_703269.html L1 - https://www.celljournal.org/article_703269_5ed54d0474243192588c3712bec10844.pdf ER -