TY - JOUR ID - 250547 TI - Toll-Like Receptor 2 (TLR-2) Gene Polymorphisms in Type 2 Diabetes Mellitus JO - Cell Journal (Yakhteh) JA - CELLJ LA - en SN - 2228-5806 AU - Ermiş Karaali, Zeynep AU - Candan, Gonca AU - Aktuğlu, Mehmet Burak AU - Velet, Mustafa AU - Ergen, Arzu AD - Department of Internal Medicine, Haseki Training and Research Hospital, University of Health Sciences, Istanbul, Turkey AD - Department of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey Y1 - 2018 PY - 2018 VL - 20 IS - 4 SP - 559 EP - 563 KW - Diabetes KW - Inflammation KW - Polymorphism KW - TLRs DO - 10.22074/cellj.2019.5540 N2 - ObjectiveInnate immunity factors are associated with type 2 diabetes (T2DM) and its complications. Therefore, T2DM has been suggested to be an immune-dependent disease. Elevated fasting glucose level and higher concentrations of innate immunity soluble molecules are not only related with insulin resistance, but inflammation is also an important factor in beta cell dysfunction in T2DM. Toll-like receptor 2 (TLR-2), which has an important role in inducing innate immune cells, is thought to have suppressive roles on immune responses in T2DM. We therefore aimed to investigate the possible role of TLR-2 del -196-174 and Arg753Gln variants in T2DM pathogenesis. Materials and Methods This study was designed as a case-control study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to genotype the two variants in 100 T2DM patients and 98 age- matched controls. Results We found significantly higher frequencies of TLR-2 del -196-174 DD genotype (P=0.003), ID genotype (P=0.009) and D allele (P=0.001) in patients compared with controls. In addition, the II genotype (P=0.001) and the I allele (P=0.003) frequencies were elevated in healthy controls. We did not find any significant differences in frequency distribution for the Arg753Gln variant in study groups. Conclusion We suggest that carrying the D allele of the TLR-2 del -196-174 variant may be related as a risk factor for T2DM. UR - https://www.celljournal.org/article_250547.html L1 - https://www.celljournal.org/article_250547_1e8430787ab18e216fb98ee13913da5e.pdf ER -