TY - JOUR ID - 250471 TI - Oral Quercetin Supplementation Enhances Adiponectin Receptor Transcript Expression in Polycystic Ovary Syndrome Patients: A Randomized Placebo-Controlled Double-Blind Clinical Trial JO - Cell Journal (Yakhteh) JA - CELLJ LA - en SN - 2228-5806 AU - Rezvan, Neda AU - Moini, Ashraf AU - Gorgani-Firuzjaee, Sattar AU - Hosseinzadeh-Attar, Mohammad Javad AD - Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, International Campus, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Obstetrics and Gynecology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran ;Department of Obstetrics and Gynecology, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, I AD - 4Department of Medical Laboratory Sciences, School of Allied Health Medicine, AJA University of Medical Sciences, Tehran, Iran Y1 - 2018 PY - 2018 VL - 19 IS - 4 SP - 627 EP - 633 KW - Adiponectin Receptors KW - Polycystic Ovary Syndrome KW - Quercetin DO - 10.22074/cellj.2018.4577 N2 - ObjectivePolycystic ovary syndrome (PCOS), an ovarian-pituitary axis androgen disorder, is a common endocrine disease in women. Obesity-induced androgenesis and imbalance of adipokine secretion may lead to some metabolic features of PCOS. The beneficial effects of polyphenolic compounds such as quercetin have been reported, however, the underlying molecular mechanism is not entirely understood. In the present study, we investigated the effect of quercetin supplementation on the expression of adiponectin receptors at the transcript level in peripheral blood mononuclear cells (PBMC) samples of PCOS patients. Materials and Methods In this randomized clinical trial, 84 PCOS subjects were randomly assigned to two groups; the treatment group received 1 g quercetin (two 500 mg capsules) daily for 12 weeks and the control group received placebo. To examine the effect of quercetin supplementation on PCOS patients in addition to biochemical and anthropometric assessments, the expression of ADIPOR1 and ADIPOR2 at the transcript level and AMPK level were determined by quantitative reverse transcription-polymerase chain reaction (RT-qPCR) and ELISA assays respectively. Results Oral quercetin supplementation significantly increased ADIPOR1 and ADIPOR2 transcript expression by 1.32- and 1.46-fold respecetively (P < 0.01). In addition, quercetin supplementation enhanced AMPK level by 12.3% compared with the control group (P < 0.05). Conclusion Oral quercetin supplementation improves the metabolic features of PCOS patients by upregulating the expression of adiponectin receptors and AMPK (Registration Number: IRCT2013112515536N1). UR - https://www.celljournal.org/article_250471.html L1 - https://www.celljournal.org/article_250471_c0abdbbd4178edb8056e230a0b705bc1.pdf ER -