TY - JOUR ID - 250448 TI - Anti-Inflammatory Effects of Curcumin on Insulin Resistance Index, Levels of Interleukin-6, C-Reactive Protein, and Liver Histology in Polycystic Ovary Syndrome-Induced Rats JO - Cell Journal (Yakhteh) JA - CELLJ LA - en SN - 2228-5806 AU - Mohammadi, Shima AU - Karimzadeh Bardei, Latifeh AU - Hojati, Vida AU - Ghorbani, Azita AU - Nabiuni, Mohammad AD - Department of Animal Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran AD - Laboratorys Animal Center and Cellular and Molecular Research Laboratory, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran AD - Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran AD - 4Department of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran Y1 - 2017 PY - 2017 VL - 19 IS - 3 SP - 425 EP - 433 KW - PCOS KW - Liver KW - curcumin KW - Insulin resistance DO - 10.22074/cellj.2017.4415 N2 - ObjectiveCurcumin protects the liver against injury and fibrosis through suppressing hepatic inflammation, attenuating hepatic oxidative stress (OS), and inhibiting hepatic stellate cells (HSCs) activation. Non-alcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS) are considered as common metabolic disorders. Low-grade chronic inflammation with different markers, such as elevated C-reactive protein (CRP) and interleukin-6 (IL-6) levels, play a crucial role in PCOS. This study aimed to evaluate the therapeutic effects of curcumin on IL-6 and CRP levels as well as insulin resistance (IR) index on liver function in PCOS rats. Materials and MethodsIn this experimental study, 90 adult Wistar rats were divided into control (n=18), sham (n=18), PCOS (n=18) and curcumin-treated PCOS groups (n=36). PCOS group was injected subcutaneously with 2 mg estradio-valerate (E2V). After 60 days, PCOS group was treated with curcumin [100 and 300 mg/kg body weight (BW)] for 14 days and anesthetized by chloroform. Blood and liver samples were collected for histological and serological analyses. Data were analyzed using In-Stat 3 via one-way analysis of variance (ANOVA). ResultsHistological and serological analyses showed a reduction in number of necrotic cells, IR index, as well as IL-6 and CRP levels in PCOS rats that were treated with various concentrations of curcumin. ConclusionIn this study, curcumin decreased liver inflammation by induction of insulin sensitivity and reduction of hepatic necrosis. Therefore, curcumin may be considered as protective factor against inflammatory state of PCOS. UR - https://www.celljournal.org/article_250448.html L1 - https://www.celljournal.org/article_250448_b307e766d93b1196399eff1483b1b483.pdf ER -