TY - JOUR ID - 250404 TI - Oxidative Stress Statues in Serum and Follicular Fluid of Women with Endometriosis JO - Cell Journal (Yakhteh) JA - CELLJ LA - en SN - 2228-5806 AU - Nasiri, Nahid AU - Eftekhari-Yazdi, Poopak AU - Karimian, Leila AU - Salman-Yazdi, Reza AU - Arabipoor, Arezoo AD - Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran AD - 5Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Bomedicine, ACECR, Tehran, Iran AD - Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran Y1 - 2016 PY - 2016 VL - 18 IS - 4 SP - 582 EP - 587 KW - Endometriosis KW - follicular fluid KW - Lipid Peroxide KW - Oxidative stress DO - 10.22074/cellj.2016.4724 N2 - ObjectiveThis study aimed to evaluate the levels of two oxidative stress (OS) markers including lipid peroxide (LPO) and total antioxidant capacity (TAC) in both serum and follicular fluid (FF) of women with endometriosis after puncture. Materials and MethodsIn this cross-sectional study, a total number of sixty-three women younger than 40 years old with laparoscopy (gold standard for endometriosis diagnosis) indication underwent in vitro fertilization (IVF) program in the Royan Institute, Tehran, Iran from September 2013 to October 2014. About forty-three patients were diagnosed with endometriosis after laparoscopy. Blood and FF from the leading follicle in each stimulated ovary were obtained at the time of egg retrieval; samples were centrifuged and frozen until assessment. At the time of sample assessment, serum and FF samples were evaluated for the levels of LPO and TAC on spectrophotometery. ResultsWe observed that women with endometriosis had significantly higher LPO and lower TAC levels in the serum and FF as compared with the control group (P < 0.05). ConclusionIt has observed that FF of women with endometriosis, regardless of disease stage, increases the proliferation power of endometrial cells in vitro, we presume that inflammatory reactions-induced OS in ovary may be responsible for proliferation induction ability in FF obtained from women with endometriosis. UR - https://www.celljournal.org/article_250404.html L1 - https://www.celljournal.org/article_250404_b5db95852db9f256b349cc682c39b7c0.pdf ER -