TY - JOUR ID - 250321 TI - MicroRNA Expression in β-Thalassemia and Sickle Cell Disease: A Role in The Induction of Fetal Hemoglobin JO - Cell Journal (Yakhteh) JA - CELLJ LA - en SN - 2228-5806 AU - Saki, Najmaldin AU - Abroun, Saeid AU - Soleimani, Masoud AU - Kavianpour, Maria AU - Shahjahani, Mohammad AU - Mohammadi-Asl, Javad AU - Hajizamani, Saeideh AD - Health Research Institute, Research Center of Thalassemia and Hemoglobinopathy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran AD - Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran AD - Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Y1 - 2016 PY - 2016 VL - 17 IS - 4 SP - 583 EP - 592 KW - MicroRNAs KW - β KW - Thalassemia KW - Sickle Cell Disease KW - Fetal hemoglobin DO - 10.22074/cellj.2016.3808 N2 - Today the regulatory role of microRNAs (miRs) is well characterized in many diverse cel- lular processes. MiR-based regulation is categorized under epigenetic regulatory mecha- nisms. These small non-coding RNAs participate in producing and maturing erythrocytes, expressing hematopoietic factors and regulating expression of globin genes by post-tran- scriptional gene silencing. The changes in expression of miRs (miR-144/-320/-451/-503) in thalassemic/sickle cells compared with normal erythrocytes may cause clinical severity. According to the suppressive effects of certain miRs (miR-15a/-16-1/-23a/-26b/-27a/-451) on a number of transcription factors [myeloblastosis oncogene (MYB), B-cell lymphoma 11A (BCL11A), GATA1, Krüppel-like factor 3 (KLF3) and specificity protein 1 (Sp1)] during β globin gene expression, It has been possible to increasing γ globin gene expression and fetal hemoglobin (HbF) production. Therefore, this strategy can be used as a novel therapy in infusing HbF and improving clinical complications of patients with hemoglobi- nopathies. UR - https://www.celljournal.org/article_250321.html L1 - https://www.celljournal.org/article_250321_43240ae20102c23437a1423766877835.pdf ER -