TY - JOUR ID - 249770 TI - Effect of Melatonin on Bone Mineral Density of Irradiated Rats JO - Cell Journal (Yakhteh) JA - CELLJ LA - en SN - 2228-5806 AU - Orbak, Zerrin AU - Ertekin, Vecdi AU - Yildirim, Mustafa AU - Ertekin, Vildan AU - Seven, Bedri AU - Karslioglu, Ihsan AD - Department of Pediatric Endocrinology, Faculty of Medicine, Atatürk University, Erzurum, Turkey AD - Department of Radiation Oncology, Faculty of Medicine, Atatürk University, Erzurum, Turkey AD - Department of Nuclear Medicine, Faculty of Medicine, Atatürk University, Erzurum, Turkey AD - Department of Pediatrics, Faculty of Medicine, Atatürk University, Erzurum, Turkey Y1 - 2011 PY - 2011 VL - 12 IS - 4 SP - 459 EP - 462 KW - Melatonin KW - Bone mineral density KW - Rat KW - Irradiation DO - N2 - Objective: Melatonin is a powerful endogenous antioxidant and it may play a role in prevention of radiation-induced damage. The aim of this study was to investigate the effect of melatonin on bone mineral density in rats receiving radiation.Materials and Methods: Sprague Dawley rats were divided into four groups. Group 1 (control group) received neither melatonin nor radiation (control group). Group 2 (Mel group) was administered intraperitoneal injections of 5mg/kg melatonin daily for ten days. Group 3 (RT group) and Group 4 were exposed to total cranium radiation of 5 Gy in a singledose by using a cobalt-60 teletherapy unit. In addition to irradiation, group 4 (RT + Mel group) was administered 5mg/kg of melatonin intraperitoneally. At the end of the 10th day, the rats' cranium and vertebrae bone mineral densities (BMDs) were measured.Results: When cranial BMDs were evaluated, statistically more significant BMD increases were seen in the Mel group and the RT + Mel groups than in the control group. No significant difference was seen in the Mel group versus the RT + Mel group; however, there was a significant difference between RT and RT + Mel groups. When vertebral BMDs were evaluated, the only significant difference was found between the control and Mel groups.Conclusion: We think that melatonin is a radioprotective agent. However, we would like to emphasize that further studies are needed before clinical trials with melatonin are initiated. UR - https://www.celljournal.org/article_249770.html L1 - https://www.celljournal.org/article_249770_7ee5d1aa7ddad1b21f46dd4dc4eac171.pdf ER -