TY - JOUR ID - 248737 TI - Effect Of Adenosine A1 Recertors Of Amygdala On Entorhinal Cortex Kindled Seizures In Rat JO - Cell Journal (Yakhteh) JA - CELLJ LA - en SN - 2228-5806 AU - Amini Komijani, A. AU - Mirnajafi-Zadeh, SJ. AU - Fathollahi, Y. AU - Motamedi, F. AD - AD - Physiology Department, School of Medicine, Tarbiat Modarres University, Tehran, Iran Y1 - 2003 PY - 2003 VL - 5 IS - 3 SP - 137 EP - 143 KW - Seizure KW - ADENOSINE KW - AMYGDALA KW - ENTORHINAL CORTEX KW - Kindling DO - N2 - Introduction: The role of adenosine A1 receptors of the amygdala on entorhinal cortex kindled seizures was investigated. Material and Methods: Animals were kindled by daily electrical stimutation of entorhinal cortex. In the full kindled animals, N6-cyclohexyladenosine (CHA 10, 50, 100, 500óM), an adenosine A1 receptor agonist and 8-cyclopentyl- 1, 3, dimethylxanthine (CPT, 10, 20 óM), an adenosine A1 receptor antagonist, were microinfused into the amygdala. Results: Data showed that CHA, only at a concentration of 500óM, decreaed entorhinal cortex and amygdala after discharge duration, stage 5 duration and seizure duration seizure duration and increased patency to stage 4 at 15 min post drug injection. Intraamygdala injection of CPT showed that it only at a concentration of 20 óM, reduced patency to stage 4. Intraamygdala pretreatment of animals by intraamygdala injection of CPT (10 óM), 5 min before CHA (500 óM), resulted in blockage of anticonvulsant effects of CHA. Conclusion: These results suggest that the amygdala may have a moderate role in seizure propagation from the entorhinal cortex and its adenosine A1 receptor activity has anticovulsant effects on entorhinal cortex kindled seizures. UR - https://www.celljournal.org/article_248737.html L1 - https://www.celljournal.org/article_248737_37bfb2b7a961f4da150158f0e0a1f34c.pdf ER -