%0 Journal Article %T Adenosine A10 Receptors Activity Of Entorhinal Cortex On Amygdala Kindled Seizures In Rat %J Cell Journal (Yakhteh) %I Royan Institute, Iranian Academic Center for Education Culture and Research (ACECR) %Z 2228-5806 %A Mohamad Zadeh, M. %A Mirnajafizadeh, J. %A Fathollahi, Y. %A Rozati, A. %D 2002 %\ 07/01/2002 %V 4 %N 2 %P 71-78 %! Adenosine A10 Receptors Activity Of Entorhinal Cortex On Amygdala Kindled Seizures In Rat %K Seizure %K AMYGDALA %K ENTORHINAL CORTEX %R %X Introduction: The role of adenosine A1 receptors of the entorhinal cortex on amygdaloid kindled seizures was investigated.Material and Methods: Animals were kindled by daily electrical stimulation of amygdala. In the full kindled animals, N6-cyclohexyladenosine (CHA; 0.1, 1 and 10 mM), an adenosine A1 receptor agonist, and 8-cyclopenthyle 1,3-dimethylexanthine (CPT), an adenosine A1 receptor antagonist, at concentrations of 1 and 5mM were injected bilaterally into the entorhinal cortex. Animals were stimulated at 5, 15, 60 and 120 min post drug infusion and kindling parameters were measured.Results: Results showed that CHA at concentration of 10 mM reduced amygdala after-discharge duration, entrorhinal cortex after-discharge duration (E-ADD) and stage 5 seizure duration at 5, 15,60 and 120 min post drug injection. It also increased the latency of stage 4 seizure. But, no alteration was observed in seizure stage. At concentrations of 1 and 0.1 mM, CHA reduced E-ADD only at 5 and 15min post drug infusion. Bilateral injection of CPT into the entorhinalcortex did not alter seizure parameters. Intra-entorhinal cortex injection of CPT (5mM), 5 min before CHA (10mM), blocked the anticonvulsant effects of CHA.Conclusion: These results suggest that the entorhinal cortex has a role in seizure propagation from the amygdala and its adenosine A1 receptors activity have anticonvulsant effects on amygdala kindled seizures. %U https://www.celljournal.org/article_248765_3ac0b402befb5fcc45a1d7d9fb707c73.pdf