%0 Journal Article %T Effect Of Adenosine A1 Recertors Of Amygdala On Entorhinal Cortex Kindled Seizures In Rat %J Cell Journal (Yakhteh) %I Royan Institute, Iranian Academic Center for Education Culture and Research (ACECR) %Z 2228-5806 %A Amini Komijani, A. %A Mirnajafi-Zadeh, SJ. %A Fathollahi, Y. %A Motamedi, F. %D 2003 %\ 09/01/2003 %V 5 %N 3 %P 137-143 %! Effect Of Adenosine A1 Recertors Of Amygdala On Entorhinal Cortex Kindled Seizures In Rat %K Seizure %K ADENOSINE %K AMYGDALA %K ENTORHINAL CORTEX %K Kindling %R %X Introduction: The role of adenosine A1 receptors of the amygdala on entorhinal cortex kindled seizures was investigated. Material and Methods: Animals were kindled by daily electrical stimutation of entorhinal cortex. In the full kindled animals, N6-cyclohexyladenosine (CHA 10, 50, 100, 500óM), an adenosine A1 receptor agonist and 8-cyclopentyl- 1, 3, dimethylxanthine (CPT, 10, 20 óM), an adenosine A1 receptor antagonist, were microinfused into the amygdala. Results: Data showed that CHA, only at a concentration of 500óM, decreaed entorhinal cortex and amygdala after discharge duration, stage 5 duration and seizure duration seizure duration and increased patency to stage 4 at 15 min post drug injection. Intraamygdala injection of CPT showed that it only at a concentration of 20 óM, reduced patency to stage 4. Intraamygdala pretreatment of animals by intraamygdala injection of CPT (10 óM), 5 min before CHA (500 óM), resulted in blockage of anticonvulsant effects of CHA. Conclusion: These results suggest that the amygdala may have a moderate role in seizure propagation from the entorhinal cortex and its adenosine A1 receptor activity has anticovulsant effects on entorhinal cortex kindled seizures. %U https://www.celljournal.org/article_248737_37bfb2b7a961f4da150158f0e0a1f34c.pdf