@article { author = {Tehrani Fateh, Sepand and Behgozin, Abbas and Yekani, Farshid and Geranpayeh, Lobat and Olfatbakhsh, Asieh and Moghaddam, Shiva and Sarami Forroshani, Ramin and Salehi-Najafabadi, Amir and Shekari, Faezeh}, title = {Healthy Male Individuals Possess Higher Plasma HER-2 Level than Females}, journal = {Cell Journal (Yakhteh)}, volume = {25}, number = {1}, pages = {73-75}, year = {2023}, publisher = {Royan Institute, Iranian Academic Center for Education Culture and Research (ACECR)}, issn = {2228-5806}, eissn = {2228-5814}, doi = {10.22074/cellj.2022.562589.1134}, abstract = {Considering HER2 as one of the well-known biomarkers in the cancer field, and published articles regarding serumlevels of HER2, in this paper we tried to highlight the issue that most studies don’t stratify the HER-2 concentrationof individuals in terms of gender. In this brief survey, healthy individuals with no prior non-communicable diseaseswere categorized as males (n=34) and females (n=43), and all samples were evaluated for plasma HER-2 levelsat once. Surprisingly, the plasma level of HER-2 of healthy male individuals (mean= 2.28 ± 0.21 ng/mL) wassignificantly (P<0.0001) higher than the plasma level of HER-2 of healthy females (mean: 0.06 ± 0.09 ng/mL),with no overlap. Therefore, we suggest that more studies are required to re-check the cutoff values for HER-2plasma levels based on gender since the clinical implications of a unique HER-2 cutoff for both genders may beseriously concerning.}, keywords = {Biomarkers,neoplasm invasiveness/diagnosis,liquid biopsy}, url = {https://www.celljournal.org/article_699767.html}, eprint = {https://www.celljournal.org/article_699767_16206cbf7c038941c45d5e403535475e.pdf} }