@article { author = {Najar, Mehdi and Fayyad-Kazan, Mohammad and Raicevic, Gordana and Fayyad-Kazan, Hussein and Meuleman, Nathalie and Bron, Dominique and Lagneaux, Laurence}, title = {Advanced Glycation End-Products-, C-Type Lectin- and Cysteinyl/ Leukotriene-Receptors in Distinct Mesenchymal Stromal Cell Populations: Differential Transcriptional Profiles in Response to Inflammation}, journal = {Cell Journal (Yakhteh)}, volume = {20}, number = {2}, pages = {250-258}, year = {2018}, publisher = {Royan Institute, Iranian Academic Center for Education Culture and Research (ACECR)}, issn = {2228-5806}, eissn = {2228-5814}, doi = {10.22074/cellj.2018.5104}, abstract = {ObjectiveWe aimed at characterizing the transcription profiles of immunological receptors associated with the biology of mesenchymal stromal cells (MSCs). Materials and Methods In this experimental study, quantitative real time-polymerase chain reaction (qRT- PCR) was performed to establish the transcription profiles of advanced glycation end-products (RAGE) receptor, C-type lectin receptors (CLRs, including DECTIN-1, DECTIN-2 and MINCLE), leukotriene B4 (LTB4) receptors (BLT1 and BLT2) and cysteinyl leukotrienes (CysLTs) receptors (CYSLTR1 and CYSLTR2) in distinct populations of MSCs grown under basic or inflammatory conditions. Results MSCs derived from adipose tissue (AT), foreskin (FSK), Wharton’s jelly (WJ) and bone marrow (BM) exhibited significantly different transcription levels for these genes. Interestingly, these transcription profiles substantially changed following exposure of MSCs to inflammatory signals. Conclusion Collectively, for the first time, our data highlights that MSCs depending on their tissue-source, present several relevant receptors potentially involved in the regulation of inflammatory and immunological responses. Understanding the roles of these receptors within MSCs immunobiology will incontestably improve the efficiency of utilization of MSCs during cell-based therapies.}, keywords = {Advanced Glycation End,Products Receptor,c,Type Lectin Receptors,Inflammation,Mesenchymal Stromal Cells}, url = {https://www.celljournal.org/article_250509.html}, eprint = {https://www.celljournal.org/article_250509_e7cc00a30d8ab65fc2dfd86b6446d0a0.pdf} }